• Based on our findings in this work

  2024-03-12

  

  Based on our findings in this work as well as the previous published data in the experimental mice model of RSV infection, we suggest that modulation of 12/15 LOX expression and/or blocking of LOX products such as 12(S)-HETE may represent potential pharmacological approaches to prevent or treat vira

• br Serine glycine and one carbon metabolism Altered

  2024-03-12

  

  Serine/glycine and one-carbon metabolism Altered serine metabolism in tumors was noted nearly half a century ago, and elevated flux through the de novo serine synthesis pathway (SSP) is a common phenomenon in cancer Rapalink-1 [43]. The SSP branches from glycolysis at the point of 3-phosphoglyce

• br Detection and possible treatments for prostate cancer PC

  2024-03-11

  

  Detection and possible treatments for prostate cancer PC can be diagnosed, by screening for prostate-specific antigen (PSA) and after diagnosis, treatments may include intense observation, radical prostatectomy, radiation, chemotherapy, hormone therapy or vaccination depending on the type and sta

• br Conflict of interest br Ethics committee

  2024-03-11

  

  Conflict of interest Ethics committee Introduction Severe combined immunodeficiency due to adenosine deaminase deficiency (ADA-SCID) is characterized by impaired function and differentiation of T, B, and natural killer (NK) cells. Non-immunological abnormalities may also occur, including fa

• We have previously reported that interfering

  2024-03-11

  

  We have previously reported that interfering with orbifloxacin receptor assembly dynamics by knocking down cofilin-1 in hMSCs increased polymerized actin that promoted osteoblast cell differentiation through a mechanism of enhancing focal adhesion kinase (FAK), p38 and c-Jun N-terminal kinase (JNK)

• br Conflict of interest statement br Benign prostatic

  2024-03-11

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal epinastine in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellular co

• In summary the role of HT and differe http

  2024-03-11

  

  In summary, the role of 5-HT and different types of 5-HTRs in gating plasticity induction in neocortical circuits remains unclear, with variable and seemingly contradictory effects reported for LTP induction in cortical sensory fields (e.g., V1, enhanced LTP: Inaba et al., 2009, Kojic et al., 1997,

• Acknowledgments br P c is

  2024-03-11

  

  Acknowledgments P450c17 is expressed in several steroidogenic tissues, including the adrenal cortex, the ovary, and the testes (). Thus, 17α-hydroxylase/17,20-lyase is a key enzyme required for the production of both cortisol and sex steroids. This enzyme defect blocks the synthesis of cortisol,

• Optimization of the B ring specifically targeted preventing

  2024-03-11

  

  Optimization of the B-ring specifically targeted preventing the oxidation of the ring system (). As described above, the 4-position of the phenyl ring provides the appropriate vector towards bulk solvent. - and -linked substitutions at the 4-position of the B-ring from the 4-fluoro-nitrophenyl inter

• cx 4945 The initial observations indicating a crucial

  2024-03-11

  

  The initial observations indicating a crucial role for cx 4945 transfer in 17,20 lyase activity were that the molar ratio of POR to P450c17 is three- to four-fold higher in porcine testes than in porcine adrenals, and that adding purified POR to porcine P450c17 in vitro increased 17,20 lyase more t

• br The future of cancer therapeutics with Aurora kinase inhi

  2024-03-11

  

  The future of cancer therapeutics with Aurora kinase inhibitors Involvement of Aurora kinases in deregulating multiple tumor suppressor and oncogenic pathways together with the preclinical findings on the efficacy of Aurora kinase inhibitors in attenuating growth of tumor dabigatran etexilate su

• br Experimental section br Acknowledgments br Introduction

  2024-03-11

  

  Experimental section Acknowledgments Introduction Adipose is a major endocrine organ which releases a range of bioactive agents [1]. Selected adipose depots have been established as sites of sex steroid metabolism [1]. Subcutaneous and visceral adipose express high levels of aromatase, cap

• To enhance the accuracy of SEs in eliminating

  2024-03-11

  

  To enhance the accuracy of SEs in eliminating cancer cells, the mAb recognized by specific A-674563 australia on tumor cells were fused with SEs. Fab C215 or C242 fused with SEA promoted apoptosis in human colon carcinoma cells via Fas (Dohlsten et al., 1994, Litton et al., 1996). SEB-incorporated

• br Introduction O Dowd et

  2024-03-11

  

  Introduction O’Dowd et al. identified a gene very similar to angiotensin type-1 receptor in 1993 (O’Dowd et al., 1993). The specific selective ligand of this receptor called APJ receptor was determined by Tatemoto et al. in 1998 as apelin (Tatemoto et al., 1998). The high expression of apelin and

• The functional observations from the present study are based

  2024-03-08

  

  The functional observations from the present study are based on neoplastic trans-4-Hydroxycrotonic acid (HSY), and comparative expressions between normal salivary and pleomorphic adenoma tissues. However, there is a paucity of information on AhR expression and function in normal salivary gland, not

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