• At present the role of autophagy in neurons remains controve

  2023-02-20

  

  At present, the role of autophagy in neurons remains controversial. Autophagy has homeostatic and waste-recycling functions and plays a protective role in neurodegeneration diseases. Moreover, it has been thought as a programmed cell death participating in the occurrence and development of various d

• br Materials and methods br Results

  2023-02-20

  

  Materials and methods Results Dried ALW-II-41-27 used were 48.46 g C. benghalensis, 857.98 g T. zebrina and 25.09 g T. fluminensis. The samples gave 12.9% C. benghalensis, 0.078% T. zebrina and 3.06% T. fluminensis methanol extracts. The methanol extracts were evaluated for their lipoxygenas

• Previous investigations have established that aromatase acti

  2023-02-20

  

  Previous investigations have established that aromatase activity is regulated via two different pathways in a tissue-specific manner. The first is a slower transcription regulatory pathway that involves an alteration in gene transcription and represents what is classically thought of as the way by w

• Expression subcellular localization transcriptional activity

  2023-02-20

  

  Expression, subcellular localization, transcriptional activity and protein stability of Foxo are regulated by proteins such as STAT3, PKB, JNK and AMPK (Sun et al., 2017; Zhang et al., 2011). STAT3 is a member of the signal transducer and activator of transcription (STAT) protein family that plays c

• Cytarabine australia Aerobic exercise plays an important rol

  2023-02-20

  

  Aerobic exercise plays an important role in the regulation of Cytarabine australia metabolism in the skeletal muscle. It is also associated with increases in AMPK and GLUT4 levels, resulting in the improvement of the glucose uptake signaling pathway [17,18]. Recently, it has been shown that exercis

• ADORs accomplish a variety of

  2023-02-17

  

  ADORs accomplish a variety of physiological effects in different tissues. In neurons, ADORs regulate the release of neurotransmitters such as dopamine and glutamate (Ferré et al., 1992; Fredholm and Dunwiddie, 1988; Ginsborg and Hirst, 1972; Gonçalves et al., 2015; Quarta et al., 2004; Stella et al.

• ADORs accomplish a variety of

  2023-02-17

  

  ADORs accomplish a variety of physiological effects in different tissues. In neurons, ADORs regulate the release of neurotransmitters such as dopamine and glutamate (Ferré et al., 1992; Fredholm and Dunwiddie, 1988; Ginsborg and Hirst, 1972; Gonçalves et al., 2015; Quarta et al., 2004; Stella et al.

• meclofenamate Plant material and growth conditions

  2023-02-16

  

  Plant material and growth conditions. Arabidopsis thaliana ecotype Columbia was grown on a mixture of soil, vermiculite, and perlite (4:2:1) with a 16h light/8h dark meclofenamate in a temperature-controlled growth room (22°C), unless indicated otherwise. Molecular cloning and plant transformation

• br Introduction The process of

  2023-02-13

  

  Introduction The process of mitosis is highly complex and tightly regulated. This phase of the 5 aminosalicylic acid resulted in two identical daughter cells. The aurora kinases (aurora A, B, and C) are a family of three highly homologous serine-threonine protein kinases that play a key role in

• Production of reactive oxygen species ROS during

  2023-02-13

  

  Production of reactive oxygen species (ROS) during RSV infection is one the important ways that neutrophils can injure the lungs [2], [24], [25]. Lipoxygenases are considered as an important source of producing ROS inside the kainate receptors [26]. Several studies have indicated that the 12/15-LOX

• Introduction Cytochrome P CYP aromatase

  2023-02-13

  

  Introduction Cytochrome P450 19 (CYP19; aromatase) catalyzes the conversion of androgens to estrogens in a three-reaction sequence, where each step depends on NADPH and O2 [[1], [2], [3]]. The first two steps are accepted to be hydroxylations of the steroid C19 methyl group, whereas the final step

• br Materials and methods br Results br

  2023-02-13

  

  Materials and methods Results Discussion In this study, we administrated BDE-153 to newborn rat pups at PND 10 and cultured primary neurons, measured neuronal apoptosis and LDH activity in vivo and in vitro, then explored the possible predominant pathway underlying the neuronal apoptosis by

• Given that the FST protocol for mice does

  2023-02-13

  

  Given that the FST protocol for mice does not engage the exposure to a previous stressful session, posits that Agtr1a levels could be kept higher by basal glutamatergic transmission rather than by stressful stimuli as postulated before. To address this possibility, we used the EMBL-EBI Expression At

• Another class of AMPK regulator is peptidyl

  2023-02-13

  

  Another class of AMPK regulator is peptidyl-prolyl cis/trans isomerase (PPIase) NIMA-interacting 1 (Pin1), which binds to a number of proteins and regulates oncogenesis and metabolic diseases (Khanal et al., 2013; Zhou and Lu, 2016). Pin1 has been shown to bind to and inhibit AMPK; therefore, at lea

• Various compounds have been designed to

  2023-02-13

  

  Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic GSK1070916 moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to be a po

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