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br Materials and methods br Results br Discussion Although
2022-03-22
Materials and methods Results Discussion Although homologues of the β-galactosidase gene were known to exist in the Xenopus genome, and SA-β-gal activity has been detected in whole-mount Xenopus embryos by histochemical staining (Davaapil et al., 2017), no reports have been presented so far
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br Materials and Methods br Results br
2022-03-22
Materials and Methods Results Discussion In the present study, we investigated the postnatal expression of the two GABA receptor subunits, GABAAα1 and GABAB1, in order to determine the differential expression and regional distribution pattern of them between right and left hippocampi in the
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We show here that FXR is a
2022-03-22
We show here that FXR is a point of convergence of heredity (H) and environmental (E) risk factors for CRC (re the Tomasetti and Vogelstein model). Our studies demonstrate that the APC mutation and high-fat diet independently and cooperatively increase the BA pool that results in the repression of F
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uPAR another newly discovered ligand has implicated FPRL
2022-03-22
uPAR, another newly discovered ligand, has implicated FPRL1 as a potential link between the fibrinolytic cascade and inflammation. uPA is a serine protease best known for its ability to regulate fibrinolysis and for its importance in tissue remodeling and tumor invasion [49]. However, uPA also induc
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br Conflicts of interest br Acknowledgment br
2022-03-22
Conflicts of interest Acknowledgment Introduction The herpes simplex virus 2 growth factor receptors (FGFRs) are a family members of receptor tyrosine kinase (RTK) that represent attractive therapeutic targets for anti-cancer therapy gaining more and more attention in recent years [1], [2].
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Cefotaxime sodium salt mg We have presented evidence that on
2022-03-22
We have presented evidence that only muscle FBPase is detectable within HL-1 cells. This is consistent with past findings of the Eschrich's group, which showed that in rat heart Cefotaxime sodium salt mg expression of FBPase is almost exclusively limited to the muscle isozyme [3]. Results of our p
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br Transportation from TGN toward plasma
2022-03-22
Transportation from TGN toward plasma membrane The insulin molecules are packaged along with other molecules such as C-peptides, amylin, Zn2+, ATP and GABA in synaptic-like macrovesicles (SLMVs, with the diameters of 50–100 nm) and large dense core vesicles (LDCVs, with the diameters of 200–500 n
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Smoking is strongly and consistently associated
2022-03-22
Smoking is strongly and consistently associated with periodontitis in the general population. In our study we detected a similar pattern in patients with HIV infection: smokers had a higher DPSI score compared to non-smokers. The exact cause of smoking as a risk factor for periodontitis in the gener
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With the aim to identify potential novel targets in
2022-03-22
With the aim to identify potential novel targets in CVD, we applied proteome analyses on vascular tissue of these frequently used mouse models of atherosclerotic disease in the presence and/or absence of diabetes. Potential targets for intervention identified with this approach were validated in hum
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Schisandrol B The H R antagonist cimetidine Tagamet became t
2022-03-22
The H2R antagonist cimetidine (Tagamet™) became the first billion-dollar drug in the 1980s for the treatment of peptic ulcer disease. Other H2R antagonists include ranitidine, famotidine, nizatidine, and zolantidine, the latter showing good BBB penetration with a steady-state brain/blood ratio of 1.
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The relationship between the attention deficit hyperactivity
2022-03-22
The relationship between the attention deficit hyperactivity disorder (ADHD) and H3Rs is supported by several reports (Berlin et al., 2011; Passani, Bacciottini, Mannaioni, & Blandina, 2000; Vohora & Bhowmik, 2012). ADHD is a neurobehavioral disorder with high prevalence in children, with hyperactiv
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br Results br Discussion Our current study demonstrates that
2022-03-22
Results Discussion Our current study demonstrates that the sustained activation of Yap overrides the p27-mediated checkpoint, at least in part, through the degradation of FoxO family proteins, allowing polyploid cells to proliferate inappropriately with mitotic defects and resulting in centros
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A complimentary approach with Per
2022-03-22
A complimentary approach with Per2:Luc DDD107498 exposed to hypoxia as well as with mBmal1:Luc circadian reporter cells in which we overexpressed variants of HIF-1α and HIF-2α revealed that hypoxia and HIFs can not only shorten the period but also decrease the amplitude of the clock (Figures 2 and
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br Materials and methods br Results To examine the
2022-03-22
Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the Methotrexate australia of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato plants. Under control c
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GCIPs are highly conserved Ca binding proteins
2022-03-21
GCIPs are highly conserved Ca2+-binding proteins first discovered in the frog [42] and later in teleost [9]. With regard to gene structure, sequence conservation, and function, GCIPs are evolutionarily related to the GCAPs. The GCIP genes have acquired an additional intron in the N-terminal region w
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