• There were significant differences in mRNA expression

  2022-03-08

  

  There were significant differences in mRNA expression levels observed for 7 out of 15 analyzed genes. This observation suggests, that selection of a reference/control group may influence interpretation of gene expression studies performed in liver pathologies. This study directly evidenced that anal

• br According to WHO estimates diabetes

  2022-03-08

  

  According to WHO 2014 estimates, diabetes continues to present an increasing health risk to the global population, affecting 422 million individuals worldwide. Type 2 diabetes (T2D), which affects the vast majority (ca. 90%) of the diabetic population, occurs when the body cannot effectively utili

• Throughout the last few decades evidence has accumulated

  2022-03-08

  

  Throughout the last few decades, evidence has accumulated indicating that NTTs, whose primary location is the cell surface, are subject to a series of regulatory processes of intracellular traffic to and from the membrane (Robinson and Jackson, 2016; Vaughan and Foster, 2013). In addition, lateral m

• CW069 br Introduction Most organisms require glucose as

  2022-03-08

  

  Introduction Most organisms require glucose as a key metabolite, and it is critical that mammalian cells regulate glucose levels properly to maintain bioenergetic homeostasis. The major transporters responsible for the uptake of glucose from systemic circulation into cells are the GLUTs, members

• GK allosteric activators validate the importance

  2022-03-08

  

  GK allosteric activators validate the importance of GK from a therapeutic perspective, but the nature of allosteric activation of GK remains unclear. The GK allosteric activator site, the pocket where GKAs bind, is ~20 Å remote from the active site (Fig. 1A). The allosteric site is the locus of man

• An advantage of photolabeling with tritiated photoprobes fol

  2022-03-07

  

  An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled Caspase-9 Fluorometric Assay Kit and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric in

• The diverse biochemistry of zinc means that in many cases

  2022-03-07

  

  The diverse biochemistry of zinc means that, in many cases, more than one factor (or pathway) is at play. Whilst catalytic Zn2+ sites are now typically well-understood, the recognition that Zn2+ levels regulate the function of many cell types has led to vigorous interest in the fate and role of mobi

• br Ferroptosis modulators With the recognition that the

  2022-03-07

  

  Ferroptosis modulators With the recognition that the small molecule erastin targets system xc- and thereby specifically triggers this form of death and that ferrostatin-1 prevents erastin-induced ferroptosis [2], it has become evident that ferroptosis is a druggable pathway with a number of tract

• br Introduction Isoprenoid structures play an essential role

  2022-03-07

  

  Introduction Isoprenoid structures play an essential role in biology and over 30,000 natural products of this class are known (Greenhagen et al., 2003). Like other animals, insects require these compounds for many disparate processes, including electron transport (e.g., ubiquinones), protein glyc

• Primaquine Diphosphate In the Medicines for Malaria Venture

  2022-03-07

  

  In 2011 the Medicines for Malaria Venture (MMV) distributed the Open-Access Malaria Box to accelerate antimalarial drug discovery (Spangenberg et al., 2013). The Malaria Box consists of 400 structurally diverse compounds, curated from >20,000 hits generated from large-scale screens, that inhibit the

• BAY 41-8543 synthesis br Application of TIRFM to visualizing

  2022-03-07

  

  Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin BAY 41-8543 synthesis (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as mast cell of m

• The strict control of Spi expression is

  2022-03-07

  

  The strict control of Spi1 expression is critical for proper myeloid cell fate determination, and genetic or epigenetic changes in the Spi1 gene frequently contribute to the leukemogenesis in mice and human. It is has been shown that Spi1 expression is frequently downregulated in human AML patients

• Small but statistically significant variance in PhyChem

  2022-03-07

  

  Small but statistically significant variance in 7 PhyChem indexes measured using intra-host HVR1 variants was shown to be strongly associated with CIP and MIP. All HVR1 sequences (N = 28,622) used here share only 6782 profiles of the selected 29 DAC’ of 7 PhyChem indexes. The significant majority (9

• Multiple studies from our laboratory and others

  2022-03-07

  

  Multiple studies from our laboratory and others, which have used stoichiometric kinetic analyses of ANP/NPRA, have provided strong evidence that bound ligand-receptor complexes are internalized and processed intracellularly, and that degraded products are released into the culture medium of various

• The vessel wall protein collagen which becomes exposed

  2022-03-07

  

  The vessel wall protein collagen, which becomes exposed to circulating platelets after vascular injuries, is a very strong platelet agonist. It stimulates all relevant platelet activation steps predominantly via the GPVI/FcRγ-chain receptor complex through an immunoreceptor tyrosine-based activation

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