• Pentamidine br Introduction Calorie restriction CR in the

  2021-12-16

  

  Introduction Calorie restriction (CR), in the absence of malnutrition, has beneficial effects on Pentamidine function, including reducing the incidence of age-related neurodegenerative disease (Gräff et al., 2013), eliciting anti-depressant behavior (Lutter et al., 2008) and improving memory fun

• Cy7 NHS ester (non-sulfonated) GOAT belongs to the super

  2021-12-16

  

  GOAT belongs to the super family of membrane-bound O-acyltransferases (MBOATs). It is encoded by the gene MBOAT4 in human. The protein GOAT is highly conserved from zebrafish to human (Yanagi et al., 2018). GOAT is ubiquitously expressed with abundant expression in the stomach and intestine (Sakata

• br Calcium permeability pathway It has been

  2021-12-16

  

  Calcium permeability pathway It has been demonstrated that physiological shear stress in the circulation causes a reversible increase in Ca2+ permeability [29], [30], [31], [32], [33] and electrophysiological evidence has been recently reported for transient activation of the Ca2+-sensitive K+ ch

• br Author contributions br Transparency

  2021-12-16

  

  Author contributions Transparency document Acknowledgments The financial contributions of the Marie-Curie Action: BIOCONTROL, contract number MCRTN – 33439, the Agence Nationale de la Recherche (projects membraneDNP 12-BSV5-0012, MemPepSyn 14-CE34-0001-01, InMembrane 15-CE11-0017-01 and the

• Methods Very briefly PLA polymeric

  2021-12-15

  

  Methods Very briefly: PLA polymeric nanoparticles as well as liposomes were synthesized and loaded with three different FGFR inhibitors. The encapsulation efficiency, average size, PDI, zeta potential, stability and release kinetics were investigated. The most promising formulations were biological

• Migration chemotaxis and trafficking of leukocytes including

  2021-12-15

  

  Migration, chemotaxis and trafficking of leukocytes, including eosinophils from the peripheral blood into the site of inflammation requires their adhesion to endothelial AP1903 (Ley et al., 2007). Despite ongoing research, the histamine effect on eosinophils adhesion to endothelium cells has not be

• br Conclusion Infections caused by the P aeruginosa could no

  2021-12-15

  

  Conclusion Infections caused by the P. aeruginosa could not be cured by current antibiotics, making multiple drug resistance of P. aeruginosa an increasing threat for human lives. Looking for a new therapeutic mechanism for infections caused by the P. aeruginosa has become a central issue. There

• br Acknowledgements This work has been supported

  2021-12-15

  

  Acknowledgements This work has been supported by TSTAR USDA and Florida Citrus Advanced Technology Program Grants to D.B., C.P and R.S. One of us (D.B.) is an established scientist fellow at the Oak Ridge Institute for Science and Education (ORISE). This research was supported in part by an appoi

• br Introduction Human immunodeficiency virus HIV is

  2021-12-15

  

  Introduction Human immunodeficiency virus-1 (HIV-1) is a retrovirus that primarily infects components of the human immune system, such as CD4+ T cells, macrophages and dendritic adrenoceptor (Clapham and McKnight, 2001). HIV directly and indirectly destroys CD4+ T cells, which leads to severe imm

• In the present study we aimed to investigate the

  2021-12-15

  

  In the present study, we aimed to investigate the effect of a common dairy and beef genetic background on the mRNA Derquantel of the AdipoQ system and GPR109A in different adipose depots and liver. Materials and Methods Results Comparing fat masses between families (fat-type vs. lean-type co

• For a long time the mechanism for the

  2021-12-15

  

  For a long time, the mechanism for the TG-lowering effect of nicotinic ML-090 has been thought that the lowered NEFA substrate from adipose tissue limits TG production from the liver (so-called NEFA hypothesis) [[1], [2], [3], [4]]. However, recent emerging evidences have suggested the involvement

• Hepcidin expression was not affected under

  2021-12-15

  

  Hepcidin expression was not affected under GlyT1 inhibition. Hepcidin downregulation is well documented in conditions of ineffective erythropoiesis and dyserythropoietic anemias, including sideroblastic anemia 33, 34. Systemic iron acquisition under these types of anemia is obviously independent fro

• Because AM had limited efficacy

  2021-12-15

  

  Because (AM-3189) had limited efficacy on rodent GPR40, we used two rodent models expressing human GPR40 to demonstrate efficacy of (AM-3189). First, we used human islet transplanted nude mice. In this model, endogenous pancreatic β-cells were ablated using streptozotocin, and mice were rescued to e

• br The hippocampus and spatial memory Numerous

  2021-12-15

  

  The hippocampus and spatial memory Numerous lines of evidence have implicated the rodent hippocampus in spatial forms of learning and memory (O’Keefe and Nadel, 1978). For example, hippocampal lesions produce robust and reliable deficits on spatial memory tasks such as the Morris watermaze in bot

• MG 262 Initially we carried out gap FRAP

  2021-12-15

  

  Initially, we carried out gap-FRAP experiments using the two-photon configuration of the confocal microscope. A SR101-positive astrocyte was targeted and a 5 × 5 μm square area was exposed to a laser illumination (5 flashes of 5 s each during 25 s). This procedure resulted in a bleaching of this ast

13971 records 496/932 page Previous Next First page 上5页 496497498499500 下5页 Last page