• br Acknowledgements br Introduction Obesity is a

  2021-11-06

  

  Acknowledgements Introduction Obesity is a growing pandemic, which becomes a global public health problem. The evidence has been readily available and mounting, demonstrating that obesity increases incidences of chronic comorbidities, such as non-alcoholic fatty liver diseases, diabetes, cardi

• However the GPR R H polymorphism

  2021-11-06

  

  However, the GPR40 R211H polymorphism was reported to affect the variation of insulin secretory capacity in other ethnic groups. The allele frequency of H211 in Japanese was 78.4%.102, 103 By comparing clinical and metabolic parameters among Japanese men, Ogawa et al. found that histidine homozygote

• In the GLUT family glucose transporter GLUT is primarily

  2021-11-06

  

  In the GLUT family, glucose transporter 1(GLUT1) is primarily responsible for basal glucose uptake and maintenance of glucose basal metabolism in cells (Olson and Pessin, 1996). High GLUT1 expression occurred in various types of human cancers, like brain tumor, lung cancer and esophageal cancer (Nis

• br Conclusions There are a number of

  2021-11-06

  

  Conclusions There are a number of factors that affect the transit of solutes through gap junction channels. Fig. 4 provides a simplified illustration of those factors. First is the cytoplasmic vestibule through which all permeable solutes must pass to gain access to the pore. In an equivalent cir

• Natural product based drug discovery can

  2021-11-06

  

  Natural-product-based drug discovery can be enhanced with computational methods [205]. Because most of the reported small-molecule natural inhibitors of fMLF-induced functional responses were not evaluated in PBIT binding assays, we used molecular modeling to predict how well these compounds fit th

• More specific quantitative assays for DiXaIs

  2021-11-06

  

  More specific quantitative assays for DiXaIs are based on the inhibition of chromogenic or clotting activity of Factor Xa. During drug development, Kubitza developed an endogenous Anti-Factor Xa assay [45], which is very sensitive to Rivaroxaban drug concentration. This assay was based on Factor Xa

• While histone modifications can alter inter nucleosomal inte

  2021-11-06

  

  While histone modifications can alter inter-nucleosomal interactions that govern the compaction state of a chromatin fiber (Francis et al., 2004, Kalashnikova et al., 2013, Lu et al., 2008), the potential impact of histone modifications on higher-order chromosome organization beyond chromatin-fiber 

• In summary we propose a model that

  2021-11-05

  

  In summary, we propose a model that explains the possible mechanism the HULC mediates activation of HBV in liver cancer Bcl Family Set I (Fig. 8). In the model, HULC promotes the expression of miR-539 by stimulating HBx-co-activated STAT3. Then, miR-539 down-regulates APOBEC3B, leading to an increa

• A few research articles described that PLGA could

  2021-11-05

  

  A few research articles described that PLGA could alone improve physiological activities in certain illnesses by exerting therapeutic effects. These reported therapeutic activities of PLGA can be appended to the hydrolysis products of PLGA lactate, glycolate, and H+. We will recapitulate their respe

• It has been shown that

  2021-11-05

  

  It has been shown that GPR55 receptors coupled to G12/13 proteins down-regulate reactive oxygen species (ROS) production and degranulation in human neutrophils [9]. MCs degranulation stimulated by IgE/Ag also requires the generation of ROS [64]; therefore, the possibility to explore the inhibitory a

• Excessive extracellular glutamate may induce excitotoxic

  2021-11-05

  

  Excessive extracellular glutamate may induce excitotoxic neuronal damage in disorders of the CNS (Schwartz et al., 2003). EAATs are considered to contribute to prevention of excitotoxicity by glutamate uptake. Our data revealed that expression levels of membrane EAAT proteins in astrocytes are much

• GLP and glucose dependent insulinotropic peptide GIP are gut

  2021-11-05

  

  GLP-1 and glucose-dependent insulinotropic peptide (GIP) are gut hormones secreted from intestinal L TNF-alpha, recombinant rat protein sale and K cells, respectively. Together, these hormones account for the vast majority of the incretin effect, the enhanced postprandial insulin secretion observed

• The intestinal epithelium is the first

  2021-11-05

  

  The intestinal epithelium is the first line of defense against pathogens and noxious agents and exerts a range of physiological activities, including digestion and Edrophonium chloride of nutrients. The intestinal wall consists of a series of finger shaped protrusions called villi and invaginations

• Recently a lot of synthetic FFA agonists

  2021-11-05

  

  Recently, a lot of synthetic FFA1 agonists containing acidic moieties have been reported (Fig. 1) [13], [14], [15], [16], [17], [18], [19], [20], [21]. Notably, most of FFA1 agonists usually have the common biphenyl scaffold, which resulted in a relative deprivation in structure types of agonists [2

• Recently some researchers working in China Pharmaceutical Un

  2021-11-05

  

  Recently, some researchers working in China Pharmaceutical University developed novel FFA1 agonists some of which were found to be efficacious in the management of type 2 diabetes and with low toxicity. For instance, Zheng et al. [48] in their in vivo study using experimental animals, reported that

13968 records 519/932 page Previous Next First page 上5页 516517518519520 下5页 Last page